Dosing & Titration

REXULTI® (brexpiprazole) offers once-daily dosing and proven efficacy at target dose of 2 or 3 mg per day

Titration schedule

Pills not actual size.

• After at least 14 days on 2 mg/day (target dose), dosage can be increased to 3 mg/day (maximum dose), based on clinical response and tolerability
• With or without food

Dose adjustments for REXULTI

• Dose adjustments may be needed in patients with hepatic or renal impairment
• Administer half the dose of REXULTI when taken with a strong CYP3A4 or CYP2D6 inhibitor or in patients who are known CYP2D6 poor metabolizers

• Administer a quarter of the dose with the concurrent use of both strong/ moderate CYP2D6 inhibitors and strong/moderate CYP3A4 inhibitors. Likewise, administer a quarter of the dose in patients who are known CYP2D6 poor metabolizers taking strong/moderate CYP3A4 inhibitors
• Double the dose over 1 to 2 weeks when administering with strong CYP3A4 inducers

Sample packs are available^a for your appropriate patients

• 14-day titration pack:
  – 7 days at 0.5 mg/day and 7 days at 1 mg/day
• 7-day single-dose packs:
  – 0.5 mg/day, 1 mg/day, 2 mg/day, 3 mg/day

^aSample packs are not for sale or reimbursement.