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Dosing information for REXULTI® (brexpiprazole)
as adjunctive treatment in adults with MDD
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Dosing and titration schedule
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REXULTI - recommended target dose: 2 mg/day
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- Dose increases should occur at weekly intervals based on the patient’s clinical response and tolerability, and should be periodically reassessed to determine the continued need and appropriate dose for treatment
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Dose increases should occur at weekly intervals based on the patient’s clinical response and tolerability, and should be periodically reassessed to determine the continued need and appropriate dose for treatment
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Dose increases should occur at weekly intervals based on the patient’s clinical response and tolerability, and should be periodically reassessed to determine the continued need and appropriate dose for treatment
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Dose adjustments for REXULTI
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- Dose adjustments may be needed in patients with hepatic or renal impairment
- Administer half the dose of REXULTI when taken with strong CYP3A4 inhibitors or in patients who are known CYP2D6 poor metabolizers
- Administer a quarter of the dose with the concurrent use of both strong/moderate CYP2D6 inhibitors and strong/moderate CYP3A4 inhibitors. Likewise, administer a quarter of the dose in patients who are known CYP2D6 poor metabolizers taking strong/moderate CYP3A4 inhibitors
- Double the dose over 1-2 weeks when administering with strong CYP3A4 inducers
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DOWNLOAD DOSING GUIDE
Download information on the titration options for initiating treatment with REXULTI for adjunctive use in adult patients with MDD.
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Consider starting your patients today
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Sample starter packs now availablea
For your appropriate adult patients with MDD, consider REXULTI sample titration packs for adjunctive use with antidepressant therapy:
- 14-day titration pack:
7 days at 0.5 mg/day and 7 days at 1 mg/day - Single-dose packs:
0.5 mg, 1 mg, 2 mg, 3 mg
aSample packs are not for sale or reimbursement.
MDD, major depressive disorder.
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Continue exploring REXULTI
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